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1

Inhibition of indoleamine 2,3-dioxygenase in human macrophages inhibits interferon-γ-induced bacteriostasis but does not abrogate toxoplasmastasis

Colin R. MacKenzie, Ralf Langen, Osamu Takikawa, Walter Däubener

Journal:

European Journal of Immunology

Year:

1999

Language:

english

File:

PDF, 142 KB

english, 1999

2

Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-γ-independent mechanism

Suwako Fujigaki, Kuniaki Saito, Kenji Sekikawa, Shigenobu Tone, Osamu Takikawa, Hidehiko Fujii, Hisayasu Wada, Akio Noma, Mitsuru Seishima

Journal:

European Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 109 KB

english, 2001

3

Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: Implications for inflammatory bowel diseases

Sílvia Barceló-Batllori, Muriel André, Catherine Servis, Nicole Lévy, Osamu Takikawa, Pierre Michetti, Marc Reymond, Emanuela Felley-Bosco

Journal:

Year:

2002

Language:

english

File:

PDF, 1.34 MB

english, 2002

4

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons

Gilles J. Guillemin, George Smythe, Osamu Takikawa, Bruce J. Brew

Journal:

Year:

2005

Language:

english

File:

PDF, 1.70 MB

english, 2005

5

Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant sprague-dawley rat

Hajime Takikawa, Naoyo Sano, Tohru Narita, Yoshinobu Uchida, Masami Yamanaka, Tohru Horie, Takashi Mikami, Osamu Tagaya

Journal:

Year:

1991

Language:

english

File:

PDF, 695 KB

english, 1991

6

Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase

Rie Hiramatsu, Toshiaki Hara, Hidetoshi Akimoto, Osamu Takikawa, Tsutomu Kawabe, Ken-ichi Isobe, Fumihiko Nagase

Journal:

Journal of Cellular Biochemistry

Year:

2008

Language:

english

File:

PDF, 382 KB

english, 2008

7

Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-κB and the generation of reactive oxygen species

Nanako Ogasawara, Takashi Oguro, Toshitsugu Sakabe, Miyoko Matsushima, Osamu Takikawa, Ken-ichi Isobe, Fumihiko Nagase

Journal:

Journal of Cellular Biochemistry

Year:

2009

Language:

english

File:

PDF, 322 KB

english, 2009

8

Characteristics of the Na/beta-alumina/Na cell as a sodium vapor pressure sensor

Osamu Takikawa, Atsuo Imai, Mituo Harata

Journal:

Solid State Ionics

Year:

1982

Language:

english

File:

PDF, 467 KB

english, 1982

9

S-Benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase

Kenji Matsuno, Kazushige Takai, Yoshinobu Isaka, Yuka Unno, Masayuki Sato, Osamu Takikawa, Akira Asai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 416 KB

english, 2010

10

Macrophages of Human First Trimester Decidua Express Markers Associated to Alternative Activation

Kristijan Cupurdija, Dagmar Azzola, Ursula Hainz, Alexei Gratchev, Andreas Heitger, Osamu Takikawa, Sergij Goerdt, Reinhold Wintersteiger, Gottfried Dohr, Peter Sedlmayr

Journal:

American Journal of Reproductive Immunology

Year:

2004

Language:

english

File:

PDF, 183 KB

english, 2004

11

High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2,3-dioxygenase in bone marrow-derived myeloid dendritic cells

Toshiaki Hara, Nanako Ogasawara, Hidetoshi Akimoto, Osamu Takikawa, Rie Hiramatsu, Tsutomu Kawabe, Ken-ichi Isobe, Fumihiko Nagase

Journal:

Immunology Letters

Year:

2008

Language:

english

File:

PDF, 505 KB

english, 2008

12

Human Epidermal Langerhans Cells Express the Immunoregulatory Enzyme Indoleamine 2,3-Dioxygenase

von Bubnoff, Dagmar, Bausinger, Huguette, Matz, Heike, Koch, Susanne, Hacker, Georg, Takikawa, Osamu, Bieber, Thomas, Hanau, Daniel, Salle, Henri de la

Journal:

The Journal of Investigative Dermatology

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

13

Brain virus burden and indoleamine-2,3-dioxygenase expression during lentiviral infection of rhesus monkey are concomitantly lowered by 6-chloro-2′,3′-dideoxyguanosine

Candan Depboylu, Todd A. Reinhart, Osamu Takikawa, Yoshinori Imai, Hitomi Maeda, Hiroaki Mitsuya, Dianne Rausch, Lee E. Eiden, Eberhard Weihe

Journal:

European Journal of Neuroscience

Year:

2004

Language:

english

File:

PDF, 361 KB

english, 2004

14

Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer

Takafumi Nakamura, Tomoko Shima, Ai Saeki, Takao Hidaka, Akitoshi Nakashima, Osamu Takikawa, Shigeru Saito

Journal:

Year:

2007

Language:

english

File:

PDF, 416 KB

english, 2007

15

Proinflammatory cytokine interferon-γ increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid β peptide 1–42: implications for the pathogenesis of Alzheimer’s disease

Akiko Yamada, Hidetoshi Akimoto, Syota Kagawa, Gilles J. Guillemin, Osamu Takikawa

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 558 KB

english, 2009

16

Reciprocal changes in endothelium-derived hyperpolarizing factor- and nitric oxide-system in the mesenteric artery of adult female rats following ovariectomy

Satoshi Nawate, Mitsuhiro Fukao, Ichiro Sakuma, Takamitsu Soma, Kazuhiko Nagai, Osamu Takikawa, Soichi Miwa, Akira Kitabatake

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 336 KB

english, 2005

17

Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide

Akira Okayama, Yasutaka Ogawa, Shigeru Goto, Atsushi Yamatodani, Hiroshi Wada, Etsuo Okuno, Osamu Takikawa, Ryo Kido

Journal:

Toxicology and Applied Pharmacology

Year:

1988

Language:

english

File:

PDF, 541 KB

english, 1988

18

OCTN2VT, a splice variant of OCTN2, does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino acids in the first extracellular loop of OCTN2

Satoshi Maekawa, Daisuke Mori, Tadashi Nishiya, Osamu Takikawa, Takahiro Horinouchi, Arata Nishimoto, Emi Kajita, Soichi Miwa

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2007

Language:

english

File:

PDF, 1.10 MB

english, 2007

19

Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium

Anna M. Hansen, Helen J. Ball, Andrew J. Mitchell, Jenny Miu, Osamu Takikawa, Nicholas H. Hunt

Journal:

International Journal for Parasitology

Year:

2004

Language:

english

File:

PDF, 623 KB

english, 2004

20

Impact of foetus and mother on IFN-γ-induced indoleamine 2,3-dioxygenase and inducible nitric oxide synthase expression in murine placenta following Toxoplasma gondii infection

Alexander W. Pfaff, Marc Mousli, Alexandre Sénégas, Luc Marcellin, Osamu Takikawa, Jean-Paul Klein, Ermanno Candolfi

Journal:

International Journal for Parasitology

Year:

2008

Language:

english

File:

PDF, 773 KB

english, 2008

21

Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells

Toshiaki Hara, Fumiyuki Yamakura, Osamu Takikawa, Rie Hiramatsu, Tsutomu Kawabe, Ken-ichi Isobe, Fumihiko Nagase

Journal:

Journal of Immunological Methods

Year:

2008

Language:

english

File:

PDF, 484 KB

english, 2008

22

Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta

Yoshiki Kudo, C.A.R. Boyd, Isabella Spyropoulou, C.W.G. Redman, Osamu Takikawa, Takafumi Katsuki, Tetsuaki Hara, Koso Ohama, I.L. Sargent

Journal:

Journal of Reproductive Immunology

Year:

2004

Language:

english

File:

PDF, 320 KB

english, 2004

23

Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma

Tomoko Inaba, Kazuhiko Ino, Hiroaki Kajiyama, Eiko Yamamoto, Kiyosumi Shibata, Akihiro Nawa, Tetsuro Nagasaka, Hidetoshi Akimoto, Osamu Takikawa, Fumitaka Kikkawa

Journal:

Gynecologic Oncology

Year:

2009

Language:

english

File:

PDF, 1.28 MB

english, 2009

24

Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy

Tomoko Inaba, Kazuhiko Ino, Hiroaki Kajiyama, Kiyosumi Shibata, Eiko Yamamoto, Shinji Kondo, Tomokazu Umezu, Akihiro Nawa, Osamu Takikawa, Fumitaka Kikkawa

Journal:

Gynecologic Oncology

Year:

2010

Language:

english

File:

PDF, 683 KB

english, 2010

25

Two Forms of Adrenodoxin Reductase from Mitochondria of Bovine Adrenal Cortex

Katsuko SUHARA, Kazuo NAKAYAMA, Masayuki KATAGIRI, Osamu TAKIKAWA

Journal:

Year:

1982

Language:

english

File:

PDF, 802 KB

english, 1982

26

Interferon-γ-Dependent Expression of Inducible Nitric Oxide Synthase, Interleukin-12, and Interferon-γ-Inducing Factor in Macrophages Elicited by Allografted Tumor Cells

Antonio Sanchez-Bueno, Vladyslav Verkhusha, Yoshimasa Tanaka, Osamu Takikawa, Ryotaro Yoshida

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 237 KB

english, 1996

27

Multiple Expression of Ly-6C and Accumulation of a Ly-6C Pre-mRNA in Activated Macrophages Involved in Rejection of an Allografted Tumor

Osamu Takikawa, Tohru Oku, Naoto Ito, Yumiko Ushio, Naoki Yamamoto, Yukio Yoneda, Junko Tsuji, Antonio Sanchez-Bueno, Vladyslav Verkhusha, Ryotaro Yoshida

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 193 KB

english, 1996

28

Indoleamine 2,3-dioxygenase in the Human Lens, the First Enzyme in the Synthesis of UV Filters

Osamu Takikawa, Tamantha K Littlejohn, Roger J.W Truscott

Journal:

Experimental Eye Research

Year:

2001

Language:

english

File:

PDF, 249 KB

english, 2001

29

Expression and Purification of Recombinant Human Indoleamine 2,3-Dioxygenase

Tamantha K. Littlejohn, Osamu Takikawa, Daniel Skylas, Joanne F. Jamie, Mark J. Walker, Roger J.W. Truscott

Journal:

Protein Expression and Purification

Year:

2000

Language:

english

File:

PDF, 99 KB

english, 2000

30

Inhibition of indoleamine 2,3 dioxygenase activity by H2O2

Anne Poljak, Ross Grant, Chris J.D. Austin, Joanne F. Jamie, Robert D. Willows, Osamu Takikawa, Tamantha K. Littlejohn, Roger J.W. Truscott, Mark J. Walker, Perminder Sachdev, George A. Smythe

Journal:

Archives of Biochemistry and Biophysics

Year:

2006

Language:

english

File:

PDF, 408 KB

english, 2006

31

Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2

Kazuhiko Nagai, Osamu Takikawa, Naoko Kawakami, Mitsuhiro Fukao, Takamitsu Soma, Atsushi Oda, Tadashi Nishiya, Misato Hayashi, Lingyun Lu, Manabu Nakano, Emi Kajita, Hiroyoshi Fujita, Soichi Miwa

Journal:

Archives of Biochemistry and Biophysics

Year:

2006

Language:

english

File:

PDF, 554 KB

english, 2006

32

Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated l-tryptophan metabolism

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 207 KB

english, 2005

33

Identification of novel kynurenine production-inhibiting benzenesulfonamide derivatives in cancer cells

Shintaro Nakano, Kazushige Takai, Yoshinobu Isaka, Susumu Takahashi, Yuka Unno, Naohisa Ogo, Kenji Matsuno, Osamu Takikawa, Akira Asai

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 663 KB

english, 2012

34

Free iron ions decrease indoleamine 2,3-dioxygenase expression and reduce IFNγ-induced inhibition of Chlamydia trachomatis infection

Birgit Krausse-Opatz, Ulrike Wittkop, Frank M. Gutzki, Cornelia Schmidt, Barbara Jürgens-Saathoff, Sabine Meier, Bibiana Beckmann, Osamu Takikawa, Michael A. Morgan, Dimitrios Tsikas, Dirk O. Stichten

Journal:

Microbial Pathogenesis

Year:

2009

Language:

english

File:

PDF, 546 KB

english, 2009

35

Neuronal localization of indoleamine 2,3-dioxygenase in mice

Edward J. Roy, Osamu Takikawa, David M. Kranz, Alicia R. Brown, Diana L. Thomas

Journal:

Neuroscience Letters

Year:

2005

Language:

english

File:

PDF, 303 KB

english, 2005

36

Tryptophan metabolism, aging and cataract

Roger J.W. Truscott, Richard McNulty, Lisa Taylor, Brian Hood, J.Andrew Aquilina, Osamu Takikawa

Journal:

International Congress Series

Year:

2002

Language:

english

File:

PDF, 102 KB

english, 2002

37

Production of truncated enzymically active human indoleamine 2,3-dioxygenase using site-directed mutagenesis

Tamantha K Littlejohn, Osamu Takikawa, Joanne F Jamie, Mark J Walker, Roger J.W Truscott

Journal:

International Congress Series

Year:

2002

Language:

english

File:

PDF, 103 KB

english, 2002

38

Indoleamine 2,3-Dioxygenase (IDO): The Antagonist of Type I Interferon-Driven Skin Inflammation?

Marina Scheler, Joerg Wenzel, Thomas Tüting, Osamu Takikawa, Thomas Bieber, Dagmar von Bubnoff

Journal:

The American Journal of Pathology

Year:

2007

Language:

english

File:

PDF, 1.56 MB

english, 2007

39

Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors

Tanaka, Minoru, Li, Xin, Hikawa, Hidemasa, Suzuki, Takafumi, Tsutsumi, Katsuhiko, Sato, Masashi, Takikawa, Osamu, Suzuki, Hideharu, Yokoyama, Yuusaku

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 733 KB

english, 2013

40

Endogenous neurotoxin quinolinic acid may play a primary role in the pathology of Alzheimer's disease by increasing the amyloid beta peptide levels

Osamu Takikawa, Syota Kagawa, Guiqin Zhang, Hiroshi Yokoi

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 41 KB

english, 2010

41

Enhancement of 3-hydroxyanthranilic acid-induced T cell apoptosis through cinnabarinic acid generation

Rie Hiramatsu, Toshiaki Hara, Hidetoshi Akimoto, Osamu Takikawa, Tsutomu Kawabe, Fumihiko Nagase

Journal:

International Congress Series

Year:

2007

Language:

english

File:

PDF, 79 KB

english, 2007

42

Up-regulation of the brain indoleamine 2,3-dioxygenase activity in a mouse model of Alzheimer's disease by systemic endotoxin challenge

Hidetoshi Akimoto, Akiko Yamada, Osamu Takikawa

Journal:

International Congress Series

Year:

2007

Language:

english

File:

PDF, 103 KB

english, 2007

43

Ido serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells

Aikou Okamoto, Takashi Nikaido, Kazunori Ochiai, Satoshi Takakura, Miho Takao, Misato Saito, Yuko Aoki, Nobuya Ishii, Nozomu Yanaihara, Kyosuke Yamada, Osamu Takikawa, Rie Kawaguchi, Seiji Isonishi, T

Journal:

International Congress Series

Year:

2007

Language:

english

File:

PDF, 580 KB

english, 2007

44

Trichloroacetic acid-triggered reaction of kynurenine with nitrite produced by bone marrow-derived myeloid dendritic cells stimulated with CpG

Toshiaki Hara, Rie Hiramatsu, Hidetoshi Akimoto, Osamu Takikawa, Tsutomu Kawabe, Fumihiko Nagase

Journal:

International Congress Series

Year:

2007

Language:

english

File:

PDF, 75 KB

english, 2007

45

Post-translational modification of indoleamine 2,3-dioxygenase: N-terminal modification and nitration

Hidetsugu Fujigaki, Kanako Takahashi, Suwako Fujigaki, Junichi Masuda, Osamu Takikawa, Sanford P. Markey, Mitsuru Seishima, Kuniaki Saito

Journal:

International Congress Series

Year:

2007

Language:

english

File:

PDF, 268 KB

english, 2007

46

Formation of a cytochrome P-450scc-adrenodoxin complex

Masayuki Katagiri, Osamu Takikawa, Hiroshi Sato, Katsuko Suhara

Journal:

Biochemical and Biophysical Research Communications

Year:

1977

Language:

english

File:

PDF, 352 KB

english, 1977

47

Indoleamine 2,3-dioxygenase–expressing antigen-presenting cells and peripheral T-cell tolerance

von Bubnoff, Dagmar, Hanau, Daniel, Wenzel, Joerg, Takikawa, Osamu, Hall, Brian, Koch, Susanne, Bieber, Thomas

Journal:

Journal of Allergy and Clinical Immunology

Year:

2003

Language:

english

File:

PDF, 194 KB

english, 2003

48

Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO)

Croitoru-Lamoury, Juliana, Lamoury, Francois M. J., Caristo, Michael, Suzuki, Kazuo, Walker, David, Takikawa, Osamu, Taylor, Rosanne, Brew, Bruce J., Ikezu, Tsuneya

Journal:

Year:

2011

Language:

english

File:

PDF, 766 KB

english, 2011

49

Vascular Endothelial Expression of Indoleamine 2,3-Dioxygenase 1 Forms a Positive Gradient towards the Feto-Maternal Interface

Blaschitz, Astrid, Gauster, Martin, Fuchs, Dietmar, Lang, Ingrid, Maschke, Petra, Ulrich, Daniela, Karpf, Eva, Takikawa, Osamu, Schimek, Michael G., Dohr, Gottfried, Sedlmayr, Peter, Chatenoud, Lucien

Journal:

Year:

2011

Language:

english

File:

PDF, 1.32 MB

english, 2011

50

Bacterial leaf spot of hemp caused byXanthomonas campestrispv.cannabisin Japan

Netsu, Osamu, Kijima, Toshio, Takikawa, Yuichi

Journal:

Journal of General Plant Pathology

Year:

2014

Language:

english

File:

PDF, 425 KB

english, 2014